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Selenium: This trace mineral is a required co-factor for the enzymes that allow glutathione to neutralize toxins

In circulation, the synthesis of NO by eNOS plays an important role in protecting vascular homeostasis by inhibiting vascular tone, platelet aggregation, as well as inflammation [41]

In addition to inducing the main phenotype of ferroptosis, the loss of GPX4 can in some cells trigger apoptosis, necroptosis, pyroptosis, or parthanatos, which mediates or accelerates developmental defects, tissue damage, and sterile inflammation