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Before operations for advanced keratoconus, patients are intolerant to wearing contact lens for long periods because the curvature of the cornea is excessively steep and thus contact lenses do not properly sit on the corneal surface, leading to lens movement, refractive irregularities and discomfort or irritation in the eye

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Their nanoscale dimensions, large surface area-to-volume ratio, and tunable surface functionality enable them to achieve site-specific drug delivery, enhance therapeutic efficacy, and minimize systemic toxicity

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Gender Generally, drugs-induced hepatotoxicity is more prevalent in females.89 A large retrospective study has recognized that 76% of all patients who developed severe liver failure due to drugs were females.1 No clear reason has been identified for this increased susceptibility to many different drugs in women

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