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One aspect that is often overlooked, however, is stereochemistry

[70] identified a potential alteration in the antioxidant system of patients with CSU

In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019

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Cytotoxicity and cellular pharmacology of 2'bromo-4'-epi-daunorubicin (WP 401), a novel non cross-resistant anthracycline analog