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Introduction Environmental factors operating on the background of hormonal factors and genetic vulnerability may be accelerating factors included in a long-held paradigm that helps explain the etiology of systemic autoimmune rheumatic disease (SARD), including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), Sjgrens disease (SjD), idiopathic inflammatory myopathies (IIM) and others ( Extensive research over the past three to four decades has elucidated the environmental factors associated with SLE ( Environmental factors and autoimmunity The development of SARD has been associated with several lifestyle behaviors

Activation of nicotinamide adenine dinucleotide phosphate hydrogen oxidase (NOX) enzymes (e.g., NOX2, NOX4) in the brain has also been implicated in paclitaxel-induced oxidative stress (Konat et al., 2020)

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Presumed to have originated in Central Europe, Blaufrnkisch is a cross between Vitis vinifera L

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Autophagy 17(11):37633775 Song JW, Guo YT, Wang D, Quan R, Wang J, Liu J (2024) Seneca valley virus 3 C protease cleaves OPTN (optineurin) to impair selective autophagy and type I interferon signaling