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Trushina, C

They have also reported the synthesis of amphiphilic micelles with lipase-cleavable ester linkage for encapsulating and releasing dexamethasone, curcumin, nimodipine, and Nile red (Fig

Phase 1b/2a Subcutaneous Formulation (Obesity) Published: The Lancet, June 2025 Participants: 125 adults with overweight or obesity (BMI 27.039.9), aged 1855 Duration: Up to 36 weeks Dosing: Once-weekly subcutaneous amycretin, up to 60 mg Results: - Up to 22% absolute weight loss at 36 weeks (highest dose group) - Placebo-adjusted difference: approximately 24% - No weight-loss plateau observed at study end Safety: 81% of the 89 participants who reported a TEAE had gastrointestinal events

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While clinical trials show it is not a replacement for stimulants in hyperactive ADHD, it demonstrates a unique ability to upregulate dopamine receptors and specifically improve symptoms in inattentive ADHD

This study was performed employing Swiss albino mice that received an acute dose of cyclophosphamide (1.5 mmol/kg, body wt, IP) along with an alcoholic extract of I