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Metabolomics analysis of plasma and erythrocytes also revealed a close relationship between childhood obesity, IR, and multiple lipid classes

10.1021/acs.bioconjchem.0c00597 93 ShengT

Conclusion: FXR314, administered orally once daily for 16 weeks, demonstrated dose dependent target engagement, improvement in hepatic fat and biochemical markers and was safe and well tolerated with a unique safety profile compared to other FXR agonists