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Z., Xin, H

Experts use a special system for the clinical management and classification of cheilitis subtypes

In the following sections, we will delve into the intricate roles of selected key genes and pathways, including IGF-1/IGF-1R signaling, MTOR, ATM, TP53, BCL2, NF-B, and STAT3 signaling, examining how their definition as aging-related factors, their complex involvement in immune modulation, and their emerging applications in therapeutic strategies collectively shape the paradoxical response to immunotherapy in the aged population