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Qatar has the highest known incidence at ~1 in 1,800 births, most likely due to the high rates of consanguineous marriages (4), while Kuwait and the eastern area of Saudi Arabia have reported comparably lower rates of 1 in 43,000 (6,7)

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Anti-TNF- therapies have shown promise in experimental MASLD models, where agents such as infliximab significantly reduced hepatic inflammation, fibrosis, and serum transaminase levels in rodent models of steatohepatitis [189]

However, these two studies were retracted, partly due to the negative results of a large scale RCT, namely the TRIPSS study

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