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In vivo , in the hippocampal tissues of mice exposed to PS-MPs, there was a significant increase in the mRNA expression levels of inflammation-related genes ( Tnf-a , Il-1b , Il-6 , Cxcl10 , and Mcp-1 ), indicating heightened inflammatory responses ( In vitro studies indicate PS has the capacity to bind to and activate BV2 microglial cells, thereby inducing pro-inflammatory reactions and activating inflammatory pathways, such as the NF-B pathway, which results in the production of pro-inflammatory cytokines ( in vitro and in vivo evidence converge to highlight oxidative stress and subsequent neuroinflammation as pivotal events in MPs-induced neurotoxicity

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92 Gao et al 22 found that poly ethylene glycol diacrylate (PEGDA) cartilage-based tissue-engineered scaffolds printed with thermal IJP achieved precise distribution and alignment of hMSCs and that the scaffolds showed natural strips of tissue structure and desirable mechanical properties

PubMed, Keene, Keith L., et al

doi: 10.1016/S0021-9258(19)74429-9 102 LanC-CEWuC-SHuangS-MWuI-HChenG-S