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Table S12)

A cardiac magnetic resonance study demonstrated that in ST-segment elevation myocardial infarction patients treated with PCI, intramyocardial hemorrhage (IMH), MVO, and residual myocardial iron deposition were observed, with heme-derived iron ions accumulating in the infarct zone while macrophages recruited by myocardial necrosis persistently release pro-inflammatory cytokines [78]

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In conclusion, the complex interplay between glycolysis, lactate metabolism and lactylation substantially contributes to the pathogenesis of tissue fibrosis