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A wide range of DDS architectures such as nanomicelles, nanoparticles, nanocapsules, and nanogels have been engineered using disulfide linkages [54]

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There is a gradient of reactive morphotypes, with the most reactive cells (border-forming astrocytes and amoeboid microglia) concentrating at the lesion perimeter, or even entering (reactive microglia) the lesion core

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