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The generated iron is repeatedly reduced, allowing this process to continue ( Oxidative stress, also known as oxidative adversity, describes a series of adaptive responses caused by the inability of the antioxidant system to remove excess oxidants promptly, causing alterations in the intracellular redox status, interfering with normal signaling, and mediating oxidative damage ( 2 O 2 and , are at a certain threshold, ROS can be used as versatile pleiotropic physiological signaling agents during the physiological activity of higher organisms ( 2 O 2 can lead to its activation, but if T cells are exposed to H 2 O 2 in vitro for a prolonged period, their DNA-binding capacity will be inhibited ( The duality of the roles of ROS is also evident in the physiological activity of T cells

Nrf2 inhibitor, brusatol in combination with trastuzumab exerts synergistic antitumor activity in HER2-positive cancers by inhibiting Nrf2/HO-1 and HER2-AKT/ERK1/2 pathways

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Inflammation Res (2020) 69(12):11819