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However, when the concentration of CORT exceeds 300 ng/ml, the protein expression level of NLRP3 gradually decreases, reaching its lowest level at 700 ng/ml, along with a decrease in activated caspase-1 expression

The authors concluded that low-dose exposure to OTA will result in early Parkinsonism when the normal age-dependent decline in dopamine levels is associated with mycotoxin exposure

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While generally considered safe, long-term or high-dose DFO administration can still lead to neurotoxicity or organ damage (Zhang et al., 2025), and it requires slow infusion due to the risk of hypotension (Gerhardsson, 2022)