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Factors such as poor diet, chronic illness, pollution exposure, and aging can reduce natural glutathione levels

Nanocarriers are taken in by diseased tissues through passive or active targeting strategies in which process achieving a controlled release of therapeutic drugs at precise sites and times is imperative for maximizing the therapeutic impact while minimizing side effects [217]

However, this review will focus on a few models illustrating the mechanisms of intrinsic cases of DILI

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