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Collectively, these three axes converge on a unified therapeutic model ( Figure 4 ): H 2 S suppresses pathological NETosis through immediate ROS-MAPK inhibition (Axis 1), intercellular danger signal disruption via platelet-neutrophil crosstalk blockade (Axis 2) and sustained epigenetic reprogramming through miR-16-5p upregulation (Axis 3)

Also, in animal models of diabetes, sorghum inhibited glucose production in the liver (gluconeogenesis) and improved insulin sensitivity

When the clinical trials from which we obtained our samples began enrollment in 2011, then-current EoE diagnostic consensus criteria required failure of an 8-week PPI trial before diagnosis ( Additionally, we did not collect self-reported smoking status from adult subjects

STRING online database ( was used for analyzing the PPI of common genes and Cytoscape software ( was employed for visualizing the PPI network of common genes in Fig 4B