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This peroxide induced a concentration-dependent increase in [Ca 2+ ] i in C6 cells which was linear for the first 10 min after applying it (Figures 2A,B)

In addition, other proteins related to 5-HT metabolism, such as tryptophan 5-hydroxylase 2 (TPH2) and nitrous oxide synthase 1 (NOS-1), which reduces the serotonin transporter (SERT or SLC6A4) cell surface localization increasing the levels of extracellular serotonin, might be involved in the pathophysiology of ADHD [90, 92]