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The FDA classified the recall as Class II, affecting multiple strengths with expiration dates from February to October 2026

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7583% achieved 15% 26% of participants on 12 mg achieved 30% weight reduction Cardiometabolic Parameters Improvements in blood pressure, HbA1c, fasting glucose, insulin, LDL-cholesterol 72% of patients with prediabetes achieved normoglycemia Safety Most common adverse events: gastrointestinal (nausea, diarrhea, constipation) , dose-dependent, predominantly mild to moderate Heart rate: slight increase up to week 24, then decrease No severe hypoglycemia, medullary carcinoma, or C-cell hyperplasia Conclusions Retatrutide induced significant, dose-dependent weight reduction of up to 24.2% over 48 weeks

So, the route of administration matters

Michelle Seguin, MD Medical Reviewer Michelle Seguin, MD, is a board-certified family medicine, lifestyle medicine, and certified functional medicine physician (IFMCP)