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Archives of Psychiatry and Psychotherapy 18(2)

Steady state studies varying NADPH and inhibitor concentrations indicate that treatment with the fast inhibitors 7 and 8 or the slow inhibitor 3 , (the only slow inhibitor reaching equilibrium in 6 h), resulted in decreases in both K m and V max values consistent with uncompetitive inhibition of TGR, while treatment with 9 , a close analog of compound 8 synthesized ad hoc to facilitate structural studies (see below), changed only the V max indicating noncompetitive inhibition (Supplementary Tables 15 and 16)

Researchers choosing between the two should base their selection on which receptor targets are relevant to their specific experimental design

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The cell-type-specific loss of Fmr1 in PV-expressing neurons led to anxiety-like behavior, impaired social behavior, and dysregulated de novo protein synthesis

J Cataract Refract Surg 35:214953, PMID: 19969222 Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA (2009) Nitric oxide in cell survival: a Janus molecule