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doi: 10.1152/ajpcell.00632.2004

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The formalin test was also performed to differentiate its anti-nociceptive effect from an inflammatory reaction or central sensitization

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Mutations in these enzymes underscore their developmental importance: Alkbh5 knockout female mice have impaired fertility owing to defective RNA metabolism in germ cells 139 , and loss-of-function mutations in FTO in mice cause growth retardation, abnormalities in brain and cardiac development, and increased perinatal lethality 140,141,142,143

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