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Part A was a double-blind, placebo-controlled, sequential, single-ascending-dose safety study of ImmTOR, and Part B was an open-label, sequential, single-ascending dose study of SEL-212, a combination product candidate consisting of a fixed dose of pegadricase combined with ascending doses of ImmTOR, in patients with hyperuricemia with or without a clinical diagnosis of gout (Fig

When this solution enters subcutaneous fat tissue (the layer beneath your skin), it can trigger mild inflammation and stimulate nerve receptors that signal a burning or stinging feeling

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doi:10.1107/S0365110X66002263