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In this analysis, we examined the impact of baseline PNPLA3 , TM6SF2 and MBOAT7 genotypes on the response to resmetirom on serial liver biopsy and MRI-PDFF (magnetic resonance imaging proton density fat fraction)

a Dynamic range determined with the excitation wavelengths given in parenthesis

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Certain thiosemicarbazones, such as NSC73306 and its derivatives, show increased toxicity against ABCB1-expressing MDR cells(Ludwig et al

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Furthermore, the higher level of intracellular ROS may damage the mitochondrial membrane and the electron-transport chain, leading to the more ROS and amplifying the oxidative imbalance, also referred to as ROS-induced ROS release (Zorov et al., 2014