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doi: 10.3390/ijms232415482 31 ChenDFZhangSXChenKEZhouBNWangPCosentinoLMet al

Cholesterol is essential for maintaining intracellular homeostasis [55], and elevated cholesterol levels within tumor cells play a crucial role in enabling evasion of immune surveillance and fostering the upregulation of inhibitory immune checkpoint genes, consequently impeding the efficacy of antitumor responses [56]

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TABLE 2 Summary of the mechanisms by which natural products intervene in MM through regulating ferroptosis