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the anti-ALPP/ALPPL2 antibodies described herein can be coupled directly to the radio-opaque moiety (e.g., at an available cysteine) or they can be attached to a "package" (e.g., a chelate, a liposome, a polymer microbead, a nanoparticle, etc.) carrying, containing, or comprising the radio-opaque material, e.g., as described below

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To bypass this impenetrable barrier, the cell relies entirely on a three-step biochemical pathway known in medical literature as the carnitine shuttle

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PMID: 41 WangTSokerSAtalaASirokyMBAzadzoiKM

Considering APOE is polymorphic in humans, the three alleles form six major genotypes ( APOE2/2, APOE3/3, APOE4/4, APOE2/3, APOE2/4, and APOE3/4 )