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Anticancer Res (2010) 30(8):31816

SARS-CoV-2 infection generates massive ROS production and the excessive oxidative damage is responsible for cytokine storm, undermined immunity, tissue damage and severe lung disease causing ARDS and death (Silvagno et al., 2020)

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108Xeljanz (tofacitinib): Initial clinical trial results of increased risk of major adverse cardiovascular events and malignancies (excluding NMSC) with use of tofacitinib relative to TNF-alpha inhibitors

Slower absorption means a more gradual, sustained release

The authors postulate that therapeutic strategies aimed at modulating glutathione levels or transporter activity might mitigate disease progression in affected individuals