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Indeed, LDHB silencing resulted in a significant increase in mitochondrial lipid peroxidation not only in the NSCLC cell line A549, the malignant pleura mesothelioma (MPM) cell line MSTO-211H, the fibrosarcoma cell line HT1080, and the pancreatic ductal carcinoma cell lines PANC-1 (Fig

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Human inflammatory dendritic cells induce Th17 cell differentiation

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While some ROS generation, produced via NADPH-dependent NOX and iNOS, is advantageous and necessary for pathogen clearance, it must be carefully titrated by antioxidant GSH which is itself regulated by NADPH-dependent glutathione reductase