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We show that GLP-1 and semaglutide, but not exendin-4 or GIP, selectively induce GLP-1R-GIPR heterodimerization, altering receptor trafficking and signaling

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Initially, both monomer 1 ( f = 1.1 ns) and 1 NF ( f = 0.4 ns) could only be found extracellularly, not inside E

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Think of it this way: the food is there, but the system that processes and distributes a key part of it is not working as it should