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Description

Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression

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(2008) Angiotensin II type 1 Receptor Blockade Corrects Cutaneous Nitric Oxide Deficit in Postural Tachycardia Syndrome

Physiol ., 7: 28-33

Similarly, the NAD + -dependent deacetylase activity of SIRT1 is also implicated as a pathogenic factor attributing to its pro-inflammatory properties in multiple autoimmune diseases such as multiple sclerosis, in which deacetylation of RORt increases its transcriptional activity, thereby enhancing Th17 cell generation and shaping pathological phenotypes