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It's best to start with a lower dose and adjust as needed

TABLE 1 Pharmacokinetic parameters of arsenic metabolites after a single intragastrical (i.g.) and intravenous (i.v.) administration of 1 mg kg 1 ATO in rats

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Durand GM, Kovalchuk Y, Konnerth A (1996)

Further studies showed that berberine enhanced the activities of glutathione peroxidase, glutathione, superoxide dismutase, and catalase, further reducing the activity of acetylcholinesterase and caspase-3, protein carbonyl, and DNA fragmentation in the hippocampus (Sadraie et al., 2019)