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On a mechanistic level, ALA effectively inhibited the activation of the HMGB1/NF-B signaling cascade (74)

Epilepsia 45 , 237242 (2004)

Notably, in most countries PAC is freely sold as an OTC drug, raising the risk of unintentional abuse and increased adverse effects ( No answer can be given to the above open questions because PAC efficacy/adverse effects, unlike most of the drugs repositioned for COVID-19 therapy, have not yet been evaluated in controlled clinical trials or analyzed through retrospective analyses

10.1002/eji.200425139 Eur

Steven M