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Dong X, Gao J, Zhang CY, Hayworth C, Frank M, Wang Z

9 However, this class of drug is associated with a high risk of cognitive impairment and delirium

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While Alnylams Phase III APOLLO-B study hit both key primary and secondary endpoints, the FDA stated in the documents that the effects of patisiran compared to placebo on both endpoints were small, of questionable clinical meaningfulness, and may not be detectable by patients. Major discussion points during the adcomm meeting included whether these key endpoints were appropriate to ascertain clinical meaningfulness in the ATTR-CM population, and panelists expressed varying opinions on whether the magnitude of the benefit seen in trial data was clinically meaningful

Increased Blood Pressure Blood Pressure Spikes: Semax may cause temporary increases in blood pressure, especially at higher doses, which could be problematic for individuals with hypertension

10 CNS+ Compounds Were Selected Accurately (Green Square), Combining BBB-PAMPA and MDR1-MDCK I Assays Figure 4