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The KPV fragment retains the anti-inflammatory properties of alpha-MSH but lacks the receptor-binding activity that causes melanocortin side effects such as skin darkening or appetite changes

In addition, as PAH mediates the conversion of phenylalanine (Phe) to tyrosine (Tyr), hyperphenylalaninemia (HPA) is present in all BH 4 deficiencies apart from autosomal dominant guanosine triphosphate cyclohydrolase I deficiency (AD-GTPCHD) and sepiapterin reductase deficiency (SRD) [1, 2]

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By engineering a patients T-cells to specifically recognize senescence-associated surface antigens, CAR-T therapy achieves highly precise targeting of SnCs