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One possible explanation of the high percentage of refractory epilepsy is that most of the AEDs available today were discovered by screening or by serendipity and their mechanisms of actions were only identified after their discovery or clinical approval (Loscher et al., 2020)

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This work was funded by the following grant: Jiangxi Provincial Natural Science Foundation Key Project 20242BAB26143 and Jiangxi Province Key Laboratory of Molecular Medicine (No