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Journal of Orthopaedic Research, 33 (7), 1024-1033

PMID: 22666519

Preclinical studies have explored GHK-Cu effects in cardiovascular applications, where the peptide demonstrates capacity to reduce atherosclerotic plaque formation in hyperlipidemic mice through anti-inflammatory effects and improved endothelial function

Inflammatory and NF-B Signaling Regulation: It downregulates pro-inflammatory mediators linked to oxidative amplification loops

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Redox Chemistry and Electron Transfer Properties GHK-Cu participates in reversible redox cycling between Cu(II) and Cu(I) oxidation states, functioning as an electron transfer mediator in biological systems