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This may also be consistent with impaired mitochondrial biogenesis as described in circulating lymphocytes in chronic inflammatory conditions (45) and in patients with idiopathic ME/CFS ( Also, we detected a reduction in serine concentration, which was inversely associated with depression and anxiety scores in LC patients

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Nevertheless, MDA levels were not associated with OM severity, suggesting a limited relationship between MDA modulation and clinical mucositis outcomes in this cohort (Fig