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A critical unanswered question is whether this immune dysregulation is a carryover from an initial infection, or whether it reflects ongoing chronic immune activation infection or inflammation when the initial infection has resolved

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Ross, K

It may inhibit the enzyme directly by blocking the enzyme's active sites so it may not perform its function, or it may do this indirectly by acting as a potent antioxidant and cause the elimination of harmful radicals

Free Radic Biol Med 95:2742 Creissen G, Firmin J, Fryer M, Kular B, Leyland N, Reynolds H, Pastori G, Wellburn F, Baker N, Wellburn A, Mullineaux P (1999) Elevated glutathione biosynthetic capacity in the chloroplasts of transgenic tobacco plants paradoxically causes increased oxidative stress

NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2 Oncogene 1999 18 : 51775186 Miyamoto S, Chiao PJ, Verma IM