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IDH 1 and 2 mutant gliomas have a more favourable prognosis compared to IDH wild-type gliomas, impacting treatment response and survival

Moreover, we observed decreased expression of enzymes involved in amino acid, carbohydrate, lipid, and nucleotide metabolism, including GPX4, IDH2, HK1, PKM1, ACADVL, ACADM, APRT, NME2, PPAT, and PFAS (Supplementary Fig

Intracellular oxidative stress is caused by the imbalance between the level of ROS and antioxidant defense

Without adequate selenium, the effectiveness of glutathione can be compromised

Since the folate pathway is closely connected with methylation and redox regulation pathways (Frye and James, Since there are two different FRAAs, blocking and blinding, our analysis determines whether the characteristics investigated are an effect of blocking or binding FRAAs independently of one another