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10.1039/d1na00697e 97 ZhengN.FuY.LiuX.ZhangZ.WangJ.MeiQ.et al (2022)

Among these, Farnesoid X Receptor (FXR) and Takeda G-protein Receptor 5 (TGR5) represent two critical BAs receptors (Wang et al., 2008)

These advantageous actions of the tested agents were accounted to their antioxidant, anti-inflammatory and anti-apoptotic properties, along with their abilities to modulate HMGB1/RAGE/JAK-2/STAT-3, PI3K/AKT/CREB/BDNF/TrkB, AMPK/SIRT-1/m-TOR and PERK/CHOP/GRP78/Bcl-2 hubs, as main contributors in the underlying pathophysiological mechanisms in MSG-induced ADHD-like behaviors (Graphical abstract)