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In addition to its use as a local anesthetic, hyaluronidase is also useful for the subcutaneous administration of drugs such as insulin, morphine, antibiotics, therapeutic monoclonal antibody, and immunoglobulins, accelerated circulation of drugs in synovial fluid speeds up pharmacokinetics, improves drug availability, and increases patient satisfaction with drug response [23, 299]

In addition, 20% bioavailability (F20), 30% bioavailability (F30), and 50% bioavailability (F50) were evaluated (Table 6)

Circ Res (2020) 126:1477500

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