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Based on the Gibbs-Helmholtz equation and the Kirchhoffs law of thermochemistry 43 , it was found that the chemical reaction (1) will occur spontaneously during the cooling process and lead to the formation of CdSe nanocrystals upon heat-treatment at low temperatures (Detailed calculation process can be found in the Electronic Supplementary Information)

While they share some overlapping areas of investigation, they differ significantly in structure, origin, and proposed mechanisms

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However, DNA demethylating agents, such as 5-aza-CdR, Zebularine, or the oligonucleotide antisense inhibitor of DNMT1, MG98 (Plummer et al., 2009), may be considered as FRDA therapeutic options in the future

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