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Addressing these dimensions will be essential for further understanding whether SLC25A45-dependent carnitine metabolism represents a universal adaptive mechanism or one selectively engaged under specific physiological or pathological conditions

The heterogeneity of study populations is another challenge

Immunofluorescence assays further revealed a marked increase in GABA signal intensity ( + 38% 360.1) associated with elevated neuronal SMN (~1-fold increase) in SMA + NUS samples compared to SMA CTRLs ( Fig.7bd)