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Additional investigations may be requested when results are equivocal or to establish the underlying cause: Holotranscobalamin (active B12) : Available in some UK laboratories and may be more sensitive for detecting early deficiency

Immunogenicity and safety of the BNT162b2 mRNA COVID-19 vaccine in adult patients with autoimmune inflammatory rheumatic diseases and in the general population: a multicentre study

The key point is that failure to respond to supplementation is information

Ideal B12 levels depend on many different factors including your age, diet, medications, and overall health

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While it may feel like coffee is bringing you back to life in many ways, you shouldnt depend on it to get alcohol out of your system