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Secondly, abnormal intracellular glucose metabolism activates the polyol pathway, leading to the accumulation of sorbitol and fructose, resulting in osmotic cell swelling [71]

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It may lead to symptoms, such as difficulty breathing, rashes, wheezing, vomiting, itching, sneezing, etc

Inefficiency of the phagocytosis process leads to the formation of residual lipid-protein granules that cannot be degraded, known as lipofuscin, and generation of ROS occurs from the constant exposure of lipofuscin to light and oxygen tension 1

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However, they have poor cell permeability 125