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Lewis et al., 2010

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Across recent studies, mechanical cues shape aging phenotypes in a rhythm- and dose-dependent manner: prolonged circadian-like compression and rapid cyclic uniaxial stretch reproducibly yield pro-aging features (greater wrinkles/roughness, elevated ROS and -gal, reduced TGF- receptor signaling, and suppressed collagen synthesis), whereas low-magnitude periodic tensile loading produces mixed, context-dependent effects on barrier-associated readouts and matrix organization 16,17,117,118

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A double-blind, randomized clinical trial of niacinamide 4% versus hydroquinone 4% in the treatment of melasma