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2022;8(01):712 71 Thomas K, Zondler L, Ludwig N, et al

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Overall, these pharmacokinetic and toxicological characteristics support NAC as a clinically suitable, safe, and bioavailable therapeutic candidate, particularly for use in ocular drug delivery systems where localized antioxidant protection and minimal systemic side effects are essential

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1 Introduction Ankylosing spondylitis (AS), a prototype of spondyloarthritis (SpA), affects the fibrous and synovial joints of the sacroiliac and spinal joints, with a prevalence estimated between 0.07% and 0.31% in the world population ( via the convergence of genetic, microbial, environmental, and immunological factors ( The microorganisms colonized in the human gastrointestinal tract mucosa are collectively called the gut microbiota or gut microbiome, which mainly includes symbiotic bacteria, fungi, and viruses