One study conducted high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy on degenerated adult human lumbar discs and demonstrated a correlation between changing metabolite concentrations and degrees of degeneration (Radek et al., 2016)
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In addition to SDF-1, several bioactive peptides have been identified as capable of recruiting stem cells

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Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation
Therefore, POL is probably a weaker detergent type of sclerosing solution than STS, and higher concentrations are necessary to produce complete vascular sclerosis