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In conditions such as I/R injury, the abrupt restoration of blood flow triggers a damaging cascade involving calcium overload and rampant oxidative stress

12 Smooth muscle receptors are also susceptible to stimulation by a variety of chemical mediators (see Figure 20-1), which may also modulate cAMP and cGMP

Tyrosine is converted to cystine in p53 (Y220C) mutant proteins, resulting in an accessible crevice

Beyond their well-established benefits in managing type 2 diabetes mellitus (T2DM) and promoting weight reduction, emerging evidence suggests that GLP-1 RAs may also offer neuroprotective, anti-inflammatory, and cardiovascular protective effects 4,5,6,7

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Mai N, Miller-Rhodes K, Prifti V et al (2019) Lung-derived SOD3 attenuates neurovascular injury after transient global cerebral ischemia