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418 Bipolar disorder (BP) Both the total number of glial cells and astrocytic densities are substantially (up to 40%) decreased in the post-mortem BP tissues, whereas numbers of neurones are not changed

Elyasi S, Hosseini S, Niazi Moghadam MR, et al

OPTIONS Study Phase 2b results announcement (AOD-9604 development terminated)

'Over time, if the condition is left unmanaged, it can result in thickened skin, damage to the eyes and a misshapen, bulbous nose.' Although rosacea is frequently seen in individuals with white skin 'the flushing, redness and dilated blood vessels are immediately noticeable and can affect one's self-confidence' Dr Fab stresses that cases in people of colour are by no means rare

74 Recent findings suggest that the demethyltransferases fat mass and obesity-associated protein in macrophages facilitate the transition from the proinflammatory M1 phenotype to the anti-inflammatory M2 phenotype, modulating inflammation and glycolysis through N6-methyladenosine modification of the neuronal PAS domain protein 2

Proteomics and cytokine analyses distinguish myalgic encephalomyelitis/chronic fatigue syndrome cases from controls