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Comprehensive Dermatologic Drug Therapy

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Akbari, M., Sogutdelen, E., Juriasingani, S

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In the development of new therapies, metabolomics has identified numerous therapeutic targets for aberrant metabolic pathways by systematically comparing the metabolic differences between cancer and surrounding tissues

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While the precise contribution of each pathway and the specific post-translational modifications on FOXO1 were beyond the scope of this study, it is plausible that KRAS-driven alterations in PI3K/AKT/mTOR, ERK and PKA signalling not only modulate FOXO1 functional state but also drive its mRNA levels through FOXO1 transcriptional autoregulation (Shen et al, 2014)

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