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Thus, the complex and cell-specific roles of HIF render it difficult to predict the net effect of HIF-PHIs in vivo , and detailed research should be carried out under each condition

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Similarly, the niche in FD appears to create a similar challenge for conventional depleting therapies

Adequate stomach acid is required to release the vitamin from the protein, and a substance called intrinsic factor is necessary to ensure its absorption

doi: 10.1016/j.msec.2015.09.025