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Hum Mol Genet 19(R1):R98R102 Laprairie R et al

the body's sensitivity to insulin is reduced, so that the biological effect of insulin on target organs is reduced and glucose uptake and utilization are reduced, thus failing to maintain blood glucose stability

The plate was then covered with plastic film and incubated for 1 h at 37 C in a shaker incubator

The mechanism: IGF-1 receptor activation in renal tubules increases sodium reabsorption, expanding plasma volume and driving fluid into interstitial spaces